42nd Annual meeting of the
European Teratology Society in Hamburg, Germany

42nd Annual meeting of the
European Teratology Society

Monday 1st to Thursday 4th September 2014, Hamburg, Germany Register now

Download the ETS Second Announcement

Table of contents

Dear Friends and Colleagues,

On behalf of the European Teratology Society Officers and Council, it is my great honour and pleasure to invite you to the 42nd Annual Meeting of the European Teratology Society.

This event will be held from Monday 1st to Thursday 4th September 2014 in Hamburg, Germany’s “gateway to the world’’.

The conference will take place in the Hotel Baseler Hof, which is conveniently located within walking distance of the Alster lake, the opera house, shopping malls and theatres.

The ETS Council has worked very hard this year to devise a scientific programme comprised of hot topics that we hope will be of interest to our established members and young scientists alike. There will be an education course, five cutting-edge scientific symposia, free/ short research communications sessions and poster presentations.

The main sessions will cover the following topics:

You are also encouraged to visit the trade exhibition, where you can keep up to date with the latest products and services offered by our sponsors.

The social events and breaks will, as always, take place in a relaxed and friendly atmosphere where new friends can be made and old acquaintances renewed. The ETS prides itself on its hospitality towards new members and students.

In addition to the blocks of rooms reserved at preferential rates for the conference delegates, cheaper accommodation options are available in Hamburg to meet all budgets.

Hamburg offers unequalled travel networks with the rest of Europe and beyond, as you would expect from Germany’s richest metropolitan area.

I look forward to welcoming you and your colleagues to the conference.

Paul Barrow,
Vice President of the ETS.


ETS Officers

President: Nina Hallmark
Past President: Elpida-Niki Emmanouil-Nikoloussi
Vice-President: Paul Barrow
Vice President elect: Manon Beekhuizen
Treasurer: Shay Giles
Secretary: Deborah Perks


ETS Council

Luc De Schaepdrijver
Geertje Lewin
Alan Hoberman
Karin Sørig Hougaard
Daniela Rahmel
Linda Allais
Edward Marsden
Gian Mario Tiboni


Meeting Organisation

Solution office e.K.
Pia Schröder
Bergstr. 2
29646 Bispingen

Tel.: +49 5194 97449-0
Fax: +49 5194 97449-4
E-mail: congress@solution-office.de 


Provisional Programme Overview

Monday 1 September

ETS Council Meeting 1



Education course:
Molecular Pathways in Embryology
Sponsored by Covance
Chairs: Gerhard Weinbauer, Michael Ohara



Gerhard Weinbauer, Covance, Germany


E-1 Signalling pathways in embryology - foundation

Nobue Itasaki, University College Dublin, Ireland


E-2 Techniques for discovering pathways that lead to dysmorphogenesis

Nicola Powles-Glover, AstraZeneca, UK





E-3 Signatures for predictive toxicology

Thomas Knudsen, US EPA, USA

Young Scientists’ Happy Hour



Welcome Reception


Tuesday 2 September

Welcome address


ETS President – Nina Hallmark

Symposium 1
Imaging Techniques
Chairs: Luc De Schaepdrijver, Edward Marsden



Luc De Schaepdrijver, Janssen, Belgium


S1-1 Imaging and morphology in reproductive toxicology - progress to date and future directions

Julian French, Morphology Consulting Ltd, UK




S1-2 Use of imaging technologies in birth defects research, a clinical perspective

Philip Loquet, Augustinus Hospital Antwerp, Belgium


S1-3 Fetal skeletal imaging with micro-CT

Colena Johnson, Merck, USA

President’s Award Lecture
Chair: Nina Hallmark


Dragons, deities and double headed monsters. A personal look at the history and understanding of conjoined twins.

Sheila Tesh, Tesh Consultants International, UK



Symposium 2
Adverse Outcome Pathways – future for DART testing
Sponsored by WIL Research
Chairs: Manon Beekhuijzen, Aldert Piersma


S2-0 Introduction of adverse outcome pathways (AOPs)

Manon Beekhuijzen,

WIL Research, The Netherlands


S2-1 Adverse outcome pathway based battery approches in an alternative strategy for reproductive toxicity testing

Aldert Piersma, RIVM, The Netherlands


S2-2 Identifying key events in AOPs for embryonic disruption by using computational toxicology

Thomas Knudsen, US EPA, NC, USA


S2-3 Using information from adverse outcome pathways and integrated testing strategies to inform on DART endpoints

Mark Cronin, John Moores University Liverpool, UK



ETS/TS Exchange Lecture
Is Lack of Mandatory Folic Acid Fortification Public Health Malpractice?
Chairs: Sue Makris, Paul Barrow


T-1 The impact of spina bifida on individuals, families and society

Margo L. Whiteford, NHS Greater Glasgow and Clyde, UK


T-2 Accelerating the pace of preventing spina bifida F and anencephaly F

Godfrey P. Oakley Jr., Emory University, USA



Poster session


Past Presidents informal dinner

19.00 -

Invitation only

Wednesday 3 September

Symposium 3
Developmental Neurotoxicology and Behaviour
Sponsored by Charles River
Chairs: Geertje Lewin, Ulla Hass


S3-1 Sensitivity of behavioral testing compared to other endpoints (endocrine disruption)

Ulla Hass, Technical University of Denmark


S3-2 Effect of inflammation on central nervous system development and vulnerability

Carina Mallard, University of Gothenburg, Sweden


S3-3 How can academic research studies fill important information gaps in regulatory risk assessment? – The example of developmental neurotoxicity of bisphenol A

Anna Beronius, University of Stockholm, Sweden




S3-4 Assessment of CNS Safety in Juvenile Animals

Jim Ridings, GSK, UK

Free communications
Chairs: Nina Hallmark, Alberto Mantovani


F-1 Persisting oxidative stress and elevated HIF1α in the offspring of Cohen diabetic rats fed a high sucrose low copper diet

Zivanit Ergaz–Shaltiel, Hebrew University Hadassah Medical School, Israel


F-2 Perinatal exposure to DOTC (di-N-octyltin dichloride) affects brain development. A study in rats using MRI (magnetic resonance imaging), [18F]FDG brain PET and genome wide gene expression profiling

Didima M. de Groot, TNO, The Netherlands


F-3 Perinatal bisphenol A (BPA) exposure causes non-monotonic dose-response relationships on some reproductive and neurobehavioural endpoints

Marta Axelstad, National Food Institute, Denmark


F-4 The European recommendations for primary prevention of congenital anomalies

Alberto Mantovani, Istituto Superiore di Sanità, Italy



Elsevier Award Lecture


A-1 Evaluation of an alternative in vitro test battery for detecting reproductive toxicants

Aldert Piersma, RIVM, The Netherlands

Symposium 4
The Role of Primary Cilia in Normal and Abnormal Development
Supported in part by March of Dimes Foundation Grant No.4-FY14-477 .
Chairs: Shay Giles, Nicola Powles-Glover



Shay Giles, University College Dublin, Ireland


S4-1 The primary cilium as an integration center for Hedgehog and Wnt signaling

Jill Helms, Stanford University, USA


S4-2 Primary cilia and teratological effects in the central nervous system

Kerry L. Tucker, University of Heidelberg, Germany




S4-3 Cilia and ciliopathies: classic examples linking phenotype and genotype

Nicola Powles-Glover, AstraZeneca, UK



ETS members only

ETS Gala Dinner


Thursday 4 September

Presentation of ETS meeting 2015


Manon Beekhuijzen, WIL, The Netherlands

Free communications


F-5 Temperatures of 32.5°C and above impact zebrafish embryonic development

Casper Pype, University of Antwerp, Belgium


F-6 Developmental toxicity assessment of tanezumab, an anti-nerve growth factor monoclonal antibody, in cynomolgus monkeys (Macaca fascicularis)

Christopher J. Bowman, Pfizer, USA

Symposium 5
Drugs in Semen
Organised by ILSI/HESI
Chair: Alan Hoberman



Jane Stewart, AstraZeneca, UK


S5-1 What fetal exposure/outcome could occur from drugs in semen? – Studies with metronidazole and thalidomide

Julia Hui, Celgene, USA


S5-2 Assessment of fetal exposure risk from seminal transfer of a therapeutic IgG4 (T-IgG4) monoclonal antibody using a rabbit model

Bill Breslin, Lilly, USA




S5-3 Nonclinical investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly vaginal administration throughout pregnancy

Graeme Moffat, Amgen, USA


S5-4 Optical imaging to assess potential intravaginal embryo-fetal exposure

Bruce K Beyer, Sanofi, USA


S5-5 Regulatory concern for seminal drug transfer and exposure to untreated partners

Lutz Wiesner, Federal Institute for Drugs and Medical Devices, Germany


Questions and discussion

Farewell Address


Paul Barrow, Roche, Switzerland

ETS Council Meeting 2



Call for Abstracts

Participants interested in giving an oral or poster presentation are invited to submit an abstract. You are especially encouraged to present work on topics related to the main symposia or the education course and ETS/TS Discussion, which can be given as free communications. Submitted abstracts will be reviewed by the ETS officers or selected experts.

Abstracts received before April 1st 2014 will be published in “Reproductive Toxicology” if accepted. Abstracts received after that date will be distributed at the meeting.

Abstract template:

Abstract deadline: 1st April 2014
Please email abstracts to: paul.barrow.pb1@roche.com by 1 April 2014.


ETS/Elsevier Prizes

In addition to the ETS Award Lecture, which is given by a long-standing and well respected member of the Society, and the Elsevier Reproductive Toxicology Publication Award Lecture, which is awarded to the best publication in the Journal of Reproductive Toxicology in 2014, there are four prizes: the ETS Prize, two Elsevier Prizes and the Teddy Edward’s Memorial Prize for Research into Congenital Malformations, awarded to the poster or free communications which best exemplify the aims of the Society.


ETS Student Travel Grants

A limited number of ETS student travel grants (250 €) are available. To qualify for a travel grant, students must submit an abstract for presentation at the conference and apply for membership to the Society. Applications should be made by the student´s Supervisor to the Secretary of the ETS.


Education Course

The Education Course this year is entitled Molecular Pathways in Embryology. We hope that you will find the Course informative, interesting and enjoyable.


Social Programme

Welcome Reception
On the evening of Monday 1st of September we would like to invite you to join us at the welcome reception in the conference venue.
This will be preceded by: Young Scientists Happy Hour, an informal get-together to foster networking opportunities for young students, researchers and professionals.

ETS Conference Dinner
The conference dinner on 3rd September will take place in the „Hotel Hafen Hamburg in the “Elbkuppel” on the top floor. This is a very traditional Hotel with a beautiful view over the river Elbe and the harbour of Hamburg.
Less respectable areas of the city are close by for those that wish to continue the revelry into the night.


ETS Annual Meeting Registration

To register for the ETS Annual Meeting please use the registration form. Using this form you will be able to pay directly by credit card (American Express, Master Card and Visa). The fees quoted are exclusive of VAT (19%). A VAT receipt will be issued to permit VATregistered companies to reclaim the additional cost.


Registration Fees

Registration Fees (19% VAT charged in addition)

Until 30 June 2014
ETS Members: € 350.00
Non Members: € 425.00
Students:* € 100.00
After 30 June 2014
ETS Members: € 420.00
Non Members: € 495.00
Students:* € 130.00

Above fees include all scientific sessions, free communications, lunch, welcome reception and ETS Conference dinner.

One-Day Registration

Until 30 June 2014
ETS Members: € 100.00
Non Members: € 130.00
Students:* € 50.00
After 30 June 2014
ETS Members: € 120.00
Non Members: € 160.00
Students:* € 60.00

One-Day fees include the ETS lectures, free communications and lunch for the registered day.

Education Course

Until June 30, 2014
ETS Members: € 70.00
Non Members: € 100.00
Students:* € 40.00
After June 30, 2014
ETS Members: € 100.00
Non Members: € 130.00
Students:* € 60.00

 * Students registration to be supported by supervisors’ letter.

Accompanying Person

Until 30 June 2014
€ 100.00
After 30 June 2014
€ 100.00 

The Accompanying Person fee includes welcome reception and ETS Conference dinner. Entrance to the scientific sessions and lunch is not included.


Meeting Organisation – Registration Queries

Solution office e.K.
Pia Schröder
Bergstr. 2
29646 Bispingen

Tel.: +49 5194 97449-0
Fax: +49 5194 97449-4
E-mail: congress@solution-office.de


Cancellation and Refund Policy

Cancellations are to be notified in writing to the ETS Conference Organizing office.
Refunds will be made under the following conditions:


Congress Venue

Hotel Baseler Hof GmbH & Co. KG
Esplanade 11
20354 Hamburg
Tel.: +49 (0)40 35 90 67 03
Fax : +49 (0)40 34 37 77



Speakers and delegates are required to make their own accommodation arrangements.

An accommodation in the Hotel Baseler Hof (congress venue) or Hotel Alster-Hof (next to the congress venue) is highly recommended. Both hotels hold a reserved contingent of rooms at special rates (by email with keyword “ETS” or by reservation form).

Hotel Adress/ contact details category single room/ night double room/ night cancellation
Baseler Hof
Congress venue
VCH Hotel Baseler Hof GmbH & Co.KG
Esplanade 11
20354 Hamburg
phone +49 (0)40 35 906 917
fax +49 (0)40 343 777
email: reservierung@baselerhof.de
134,00 € 164,00 € There is no charge for cancellations up to 48 hours prior to arrival.
Next to the congress venue
Hotel Alster-Hof
Esplanade 12
20354 Hamburg
phone :+49 (0)40/350070
fax : +49 (0)40/35007514
email: info@alster-hof.de
S 90,00 € 125,00 € There is no charge for cancellations up to 8 weeks prior to arrival.
Up to 4 weeks prior arrival there will be a charge of 50%.

For reservation in the Hotel "Baseler Hof" please download the reservation form and send it to the hotel by mail or fax. Or send an email to "reservierung@baselerhof.de" with the keyword "ETS" and your registration details.

For reservation in the Hotel "Alster-Hof" please send an email to "info@alster-hof.de" with the keyword "ETS" and your registration details.

There are several other hotels in different categories in walking distance or with public transport connection. For example:

Vorbach Hotel ***
Johnsallee 63-67
20146 Hamburg

ibis Hamburg Alster Centrum **
Holzdamm 4-12 + 16
20099 Hamburg

Mercure Hotel Hamburg Mitte ****
Schroederstiftstr. 3
20146 Hamburg

Motel One Hamburg am Michel
Ludwig-Erhard-Straße 26
20459 Hamburg

For other hotels please check: www.hrs.com


Climate in Hamburg

In September and October, the weather in Germany can still be pleasant (sometimes), with golden days ablaze in colourful autumn foliage. Germans call these last warm days of the year “Altweibersommer” (Indian summer). The German climate, however, is unpredictable; so be prepared for possible showers and cool temperatures. The German word for weather, “wetter”, sums it up.

For everyday weather visit: www.wetter.com


Travel information - How to get to Hamburg

By plane
Hamburg has the fifth largest international airport in Germany, so arrival by plane is an obvious choice for those visiting from far away. There are plenty of connections within Europe and a few intercontinental direct flights.

Hamburg Airport is connected to the city by the S-Bahn S1 commuter train line, which connects to the Central Station (Hauptbahnhof) and the city centre in about 30 minutes.

There are trains every 10-20 minutes, and a single fare is about € 3. When leaving the city centre for the airport, be sure to get into one of the first three cars (unless you want to visit the suburb of Poppenbüttel): all trains are divided at Ohlsdorf. A bus service runs along the same route between midnight and 04:00H.

By train
Hamburg has five major stations: Hauptbahnhof (central station), Altona, Dammtor, Harburg and Bergedorf.

The Hotel Baseler Hof is easily reachable from the Hauptbahnhof and Dammtor. Various types of train service are available.

ICE (Inter City Express) high speed train service to or from most major German cities, including Berlin, Cologne (Köln), Dusseldorf, Frankfurt and Munich, also Basel and Zurich.

There is usually an hourly service to most destinations during the daytime.
Direct trains run to or from Copenhagen, Budapest, Prague, Vienna, and Bratislava.
Use the German railway’s online trip planner to find connections to/from Hamburg and buy tickets:

By car
Follow your GPS!
Be prepared to pay for parking in the city centre. Hamburg has many free P+R (Park+Ride) car parks outside the city centre, from where you can easily take public transport into the city.



English is the language of the meeting.
No translation facilities will be provided.


Currency & Exchange

Germany is a member of the Economic and Currency Union and the common currency is the Euro. Currency can be exchanged at the airport, banks and exchange offices.
ATMs are available in many parts of Hamburg – ensure you inform your bank before travelling abroad, and be aware you may be charged for cash withdrawals. It is advisable to exchange some cash before arriving in Hamburg.



Non-EU nationals may need to apply for a visa to travel to Germany. Please consult the following link:


Letter of invitation

If you need a letter of invitation for your visa please contact the congress organizer Pia Schröder at solution office.

Please note that a letter of invitation will only be issued after you have registered for the congress.


Sponsors & Exhibitors

Thanks to our sponsors and exhibitors

We are pleased to invite you to be an exhibitor or sponsor at the 42nd annual meeting of the European Teratology Society (ETS) to be held from 1-4 September 2014 in the Hotel Baseler Hof in the wonderful city of Hamburg.

For more informtion please see the invitation letter and application form for sponsors & exhibitors.

Invitation letter 2014 Application for sponsorship and exhibition 2014