Bologna, Italy, September 2024
Sunday 15th SeptemberHot topics symposium: Artificial placenta, cannabinoids, artificial Intelligence, ChatGPT and machine learning
Chairs: Arantza Muriana and Marta Barenys-Espadaler
- 14:00-14:15 Introduction (Arantza Muriana, Biobide)
- 14:15-15:00 In silico methods in reprotoxicology: current and future perspectives (Markus Frericks, BASF)
- 15:00-15.45 From model to clinic: implementing model-based drug dosing protocols in pregnancy care ( Rick Greupink, Radboud University)
- 15:45-16:15 COFFEE BREAK
- 16:15-17:00 New approach methodologies to confirm developmental toxicity of pharmaceuticals based on weight of evidence (Chris Bowman, Pfizer)
18:00: Welcome reception
Monday 16th September
Symposium 1: Recent developments in regulatory DART studies: ED & CLP changes, changes in REACH regulation (type of DART studies required, second species)
Chairs: Steven van Cruchten, University of Antwerp
- 09:00-09:45 Current use of NHPs for DART studies in pharmaceutical testing (Alan Hoberman, CRL)
- 09:45-10:30 DART strategies for mAbs: an industry perspective ( Jane Stewart, Apconix)
- 10:30-11:00 COFFEE BREAK
- 11:00-11:45 DART strategies for oligos: an industry perspective (Bethany Hannas, Eli Lilly)
- 11:45-12:30 DART strategies for new therapeutic modalities: a regulatory perspective (Puck Roos, MEB)
- 12:30-13:30 LUNCH
- 13:30-14:30 Transfer to DIMEVET
Free Communications:
Chair: Bernd Baier, Boehringer Ingelheim
Tuesday 19th September
9:15- 10:00: President’s Award Lecture “Fetal Pathology (or should that be Foetal Morphology) - 40 years of change?” (Julian French, Toxiqua)
Symposium 2: Resent developments in regulatory DART studies: ED & CLP changes, changes in REACH regulation (type of DART studies required, second species)
Chair: Emily Richmond, Exponent
- 10:00-10:20 Environmental risk assessment – wild birds and mammals (Gero Eck, Exponent)
- 10:20-10:50 Handling ED across different regions ( Simon Craige, EDGE Toxicology Consulting)
- 10:50-11:10 The impact of the changing REACH requirements for ED (Lauren Kent, Corteva)
- 11:10-11:40 COFFEE BREAK
- 11:40-12:20 DART dose selection issues with ECHA – an update (Hrista Karapeneva, Exponent)
- 12:30-13:30 LUNCH
- 13:30-14:30 ETS/BDRP exchange lecture “Comparing FDA and EMA Labelling on Pregnancy, Lactation & Fertility” (Helen-Marie Dunmore, Charles River and Leyla Sahin, US FDA)
Free Communications:
Chair: Bernd Baier, Boehringer Ingelheim
- 14:30-14:50 Teratogenic and Neurobehavioral Effects of Ethanol Using the Alternative Method R-FETAX (Elena Menegola)
- 14:50-15:10 Repurposing Transgender Testicular Tissue: Androgenic Testicular Organoids for High Throughput Applications (Samuel Madureira Silva)
15:10-15:30 A Harmonized Testing Paradigm for Assessing Egocentric Learning and Memory in the Biel Water Maze in Rats (Charlotte Verchere-Beau)
15:30-16:00. COFFEE BREAK
16:00-18:00: AGM (ETS members-only)
20:00: Conference Dinner
Wednesday 18th September
9:00-9:40: Elsevier Award Lecture “Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro”
Symposium 3: Fertility in DART testing
Chair: Nicola Powles-Glover
- 9:40-09:50 Introduction
- 09:50-10:30: How can cold-blooded vertebrates provide models for endocrine-related reproductive toxicity in mammals? (Annalisa Zaccaroni, University of Bologna)
- 10:30-11:00: COFFEE BREAK
- 11:00-11:40: Sperm assessments in zebra fish (Arantza Muriana, Biobide)
- 11:40-12:20: AOP-based approaches to past findings on male reproductive toxicity (Alberto Mantovani, University of Milan)
- 12:20-12:35: Farewell Address
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