Agenda: European Teratology Society Education Course

Was run in 2024:

The course was run between 9am till 6pm each day.

5^th February 2024

Basic Physiology and Reproduction: Peter Bols, Steven Van Cruchten and Wendy Halpern (Presentor Wendy Halpern online)

• Male and Female Reproductive Physiology
• Comparative placentation
• Embryology: From Fertilization to Neural Tube/Somite Formation
• Endocrine System in reproduction and developing organisms

Welcome Drink

6^th February 2024

Organ Development: John and Sheila Tesh, Geertje Lewin and Didima de Groot

• CV
• Respiratory and GI System
• Nervous system (+ Behaviour)
• Craniofacial development
• Case Study

7^th February 2024

Regulatory Reproductive toxicity testing I: Paul Barrow, Graham Bailey, John Tesh and Sheila Tesh

• Regulatory Reproductive and Developmental Toxicology - Basics
• Male/Female Fertility Testing
• Developmental Toxicity Testing
• Foetal morphology
• Case study
• PPN
• Juvenile Animals Toxicity Testing
• Case Study

8^th February 2024

Regulatory Reproductive toxicity testing II: Pieter Annaert, Alan Hobermann, Maaike Schutte and Emily Richmond

• PK/ADME of Xenobiotics/Chemicals during Pregnancy/Lactation and in Fetus/Newborn
• Risk Assessment for Pharmaceuticals
• Agricultural and Industrial Chemical testing for reproduction toxicity testing in Europe
• EOGRT - basic principles
• Case study
• Endocrine Disruptor testing in Europe

9^th February 2024

"Non-Classical" Methods and Future Perspectives: Steven Van Cruchten, Sonja Beken (FAMHP, Belgium), Aldert Piersma, Peter Theunissen, Nicola Powles-Glover, Amer Jamalpoor, Arantza Muriana, Jason Manton, Peter Van Meer and Emily Richmond

• Regulatory Reproductive and Developmental Toxicology - Basics Recap (BelTox only)
• The revision of ICH S5(R3)
• 3R testing approaches or NAMs for reproductive toxicity testing – General considerations
• Revised ICH S5 guideline - general aspects and qualification of alternative testing approaches
• Use of NAMs or 3R testing approaches for reproductive toxicity testing of pharmaceuticals
• Use of NAMs or 3R testing approaches for reproductive toxicity testing of chemicals
• Alternative approaches to non-human primate use for reproductive toxicity testing
• EOGRTS: what, pros and cons, experience, future 

A brief examination of each days course will be conducted (at the end of) each day